The alliance between Iran and Syria has been an important and persistent feature on the political landscape of the Middle East for more than three decades. The eruption of the Syrian uprising in the spring of 2011 has presented the greatest challenge to the survival of the Tehran-Damascus nexus. Does this signify the end of the partnership? This article provides a brief overview of the relationship and a detailed analysis of the evolution of Iran’s policies, perspectives, interests, and options in the ongoing Syrian crisis.