The subnational level of the US-China relationship has become increasingly important but remains poorly understood. Over the past several decades, many US states have engaged extensively with Chinese official counterparts to promote economic development, educational cooperation, and cultural exchange. Once routine, these forms of subnational interaction with China have attracted fresh scrutiny and grown politically fraught amid worsening US-China relations. In this essay, I examine the stakes of state-level engagement with China and the challenges that have arisen as low politics and high politics blur together, considering the dual risks for US states of unbalanced engagement and radical recoil. To better understand how states are navigating a rapidly changing US-China relationship, I carry out a detailed case study of Indiana-China interaction while also exploring broader nationwide trends. Through this analysis, I develop insights into the drivers of both historical moderation and recent volatility in state-level relations with China, and I distill lessons and recommendations for policymakers at both the state and federal level.